Mutation-induced spatial differences in neuraminidase structure and sensitivity to neuraminidase inhibitors

Yang Zhi-wei^{1, 2, 3}, Hao Dong-xiao¹, Che Yi-zhuo¹, Yang Jia-hui¹, Zhang Lei^{1, ‡}, Zhang Sheng-li^{1, §}

(color online) Comparison of the various NA subtype active sites. Structures of the active site in 09N1 (PDB ID 3NSS), VN04N1 (PDB ID 2HTY), N2 (PDB ID 1NN2), N3 (PDB ID 4HZV), N4 (PDB ID 2HTV), N5 (PDB ID 3SAL), A/chicken/Nanchang/7-010/2000 (H3N6) N6, A/mallard/ALB/196/1996 (H10N7) N7, N8 (PDB ID 2HT5), N9 (PDB ID 7NN9), N10 (PDB ID 4FVK), N11 (PDB ID 4K3Y), Flu B NA (B/Beijing/1/87; PDB ID 1NSB), and 09N1-Ile223Arg (PDB ID 4B7M) (N1 numbering).^[3]