The birhythmicity increases the diversity of p53 oscillation induced by DNA damage

Wang Dao-Guang^{1, 2}, Zhou Chun-Hong², Zhang Xiao-Peng^{1, 3, †}

(color online) Dependence of [p53_p] on and with . (a) Bifurcation diagram of [p53_p] versus characterizing the strength of ATM phosphorylation. (b) Bifurcation diagram of [p53_p] versus representing the strength of ATM dephosphorylation. The inset shows the oscillation period. The symbols ‘HB’ and ‘SN’ denote Hopf bifurcation and saddle-node bifurcation, respectively.