The birhythmicity increases the diversity of p53 oscillation induced by DNA damage

Wang Dao-Guang^{1, 2}, Zhou Chun-Hong², Zhang Xiao-Peng^{1, 3, †}

(color online) With different initial values, the p53 network shows distinct oscillatory modes. (a) Temporal evolution of [ ], [ATM_p], and [Mdm2_n] under different initial conditions. (b) Trajectories in the [p53_p]–[ATM_p] planes. Two separate limit cycles are shown by the lines in different colors.