The birhythmicity increases the diversity of p53 oscillation induced by DNA damage
Wang Dao-Guang1, 2, Zhou Chun-Hong2, Zhang Xiao-Peng1, 3, †
       

(color online) Schematic diagram of the network model. DNA damage activates ATM, which phosphorylates and accelerates degradation of nuclear Mdm2, thus stabilizing and activating p53. Phosphorylated p53 induces the production of Mdm2 and Wip1, and Wip1 dephosphorylates ATM and p53.