Computational study of non-catalytic T-loop pocket on CDK proteins for drug development<xref rid="cpb_26_12_128702_fn1" ref-type="fn">*</xref> <fn id="cpb_26_12_128702_fn1"> <label>*</label> <p>Project supported by the National Natural Science Foundation of China (Grant No. 11704140), the Natural Science Foundation of Hubei Province, China (Grant No. 2017CFB116), the Thousand Talents Plan (Grant No. 31103201603), and the Self-determined Research Funds of CCNU from the Colleges’ Basic Research and Operation of MOE 20205170045 to YZ.</p> </fn>

Computational study of non-catalytic T-loop pocket on CDK proteins for drug development* *

Project supported by the National Natural Science Foundation of China (Grant No. 11704140), the Natural Science Foundation of Hubei Province, China (Grant No. 2017CFB116), the Thousand Talents Plan (Grant No. 31103201603), and the Self-determined Research Funds of CCNU from the Colleges’ Basic Research and Operation of MOE 20205170045 to YZ.

Wang Huiwen¹, Wang Kaili¹, Guan Zeyu¹, Jian Yiren^{2, 4}, Jia Ya¹, Kashanchi Fatah³, Zeng Chen^{1, 2, †}, Zhao Yunjie^{1, ‡}

(color online) Ribbon representation of the parasite CDK Pfmrk and human Cyclin H complex. The structure was built via homology modeling by I-TASSER using human CDK7 and Cyclin H complex. Pfmrk is colored in green. Cyclin H is colored in light blue.