Bloom’s syndrome protein unfolding G-quadruplexes in two pathways

Zhao Zhen-Ye^{1, 2}, Xu Chun-Hua^{1, 2}, Shi Jing³, Li Jing-Hua⁴, Ma Jian-Bing^{1, 2}, Jia Qi^{1, 2}, Ma Dong-Fei^{1, 2}, Li Ming^{1, 2}, Lu Ying^{1, 2, †}

(color online) Proposed model for the two unfolding pathways of G4 by BLM. (a) HRDC domain of BLM, which is free in G4 unfolding. (b) HRDC domain, which binds to G4 when BLM unfolds G4.