Bloom’s syndrome protein unfolding G-quadruplexes in two pathways

Zhao Zhen-Ye^{1, 2}, Xu Chun-Hua^{1, 2}, Shi Jing³, Li Jing-Hua⁴, Ma Jian-Bing^{1, 2}, Jia Qi^{1, 2}, Ma Dong-Fei^{1, 2}, Li Ming^{1, 2}, Lu Ying^{1, 2, †}

(color online) Unfolding of G4 by BLM without the HRDC domain. (a) BLM mutation without the HRDC domain used in this study. (b) A FRET trace of unfolding G4 with 200-μM ATP. (c) Histograms of dwelling times for the completely unfolded G4.