Computational design of proteins with novel structure and functions
Yang Wei1, 2, 3, Lai Lu-Hua1, 2, †,
       

Computationally designed protein–protein interactions. (a) Design of proteins bind a conserved surface of influenza hemagglutinin (HA).[64](b) Design of small protein mimicking viral epitope with the capability of inducing potent neutralizing antibodies.[67](c) Design of non-natural protein–protein interaction by hot-spots grafting.[63](d) Design of helix peptide targeting TNF with novel sequence and interaction pattern.[66]