Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein

doi:10.1088/1674-1056/27/2/028708

中国物理B ›› 2018, Vol. 27 ›› Issue (2): 28708-028708.doi: 10.1088/1674-1056/27/2/028708

所属专题： TOPICAL REVIEW — Soft matter and biological physics

• SPECIAL TOPIC—Soft matter and biological physics (Review) • 上一篇下一篇

Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein

Lu Gou(缑璐), Taoli Jin(金桃丽), Shuyu Chen(陈淑玉), Na Li(李娜), Dongxiao Hao(郝东晓), Shengli Zhang(张胜利), Lei Zhang(张磊)

Department of Applied Physics, School of Science, Xi'an Jiaotong University, Xi'an 710049, China

收稿日期:2017-08-31 修回日期:2017-12-13 出版日期:2018-02-05 发布日期:2018-02-05
通讯作者: Lei Zhang E-mail:zhangleio@mail.xjtu.edu.cn
基金资助:
Project supported by the National Basic Research Program of China (Grant No. 2015CB856304) and the National Natural Science Foundation of China (Grant Nos. 11504287 and 11774279).

Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein

Lu Gou(缑璐), Taoli Jin(金桃丽), Shuyu Chen(陈淑玉), Na Li(李娜), Dongxiao Hao(郝东晓), Shengli Zhang(张胜利), Lei Zhang(张磊)

Department of Applied Physics, School of Science, Xi'an Jiaotong University, Xi'an 710049, China

Received:2017-08-31 Revised:2017-12-13 Online:2018-02-05 Published:2018-02-05
Contact: Lei Zhang E-mail:zhangleio@mail.xjtu.edu.cn
About author:87.64.Ee; 87.80.-y 87.15.B-; 87.15.H-
Supported by:
Project supported by the National Basic Research Program of China (Grant No. 2015CB856304) and the National Natural Science Foundation of China (Grant Nos. 11504287 and 11774279).

摘要/Abstract

摘要：

Bio-macromolecules, such as proteins and nucleic acids, are the basic materials that perform fundamental activities required for life. Their structural heterogeneities and dynamic personalities are vital to understand the underlying functional mechanisms of bio-macromolecules. With the rapid development of advanced technologies such as single-molecule technologies and cryo-electron microscopy (cryo-EM), an increasing number of their structural details and mechanics properties at molecular level have significantly raised awareness of basic life processes. In this review, firstly the basic principles of single-molecule method and cryo-EM are summarized, to shine a light on the development in these fields. Secondly, recent progress driven by the above two methods are underway to explore the dynamic structures and functions of DNA, antibody, and lipoprotein. Finally, an outlook is provided for the further research on both the dynamic structures and functions of bio-macromolecules, through single-molecule method and cryo-EM combining with molecular dynamics simulations.

关键词: bio-macromolecule, single-molecule method, cryo-electron microscopy, electron tomography

Abstract:

Key words: bio-macromolecule, single-molecule method, cryo-electron microscopy, electron tomography

中图分类号: (Electron microscopy)

87.64.Ee

87.15.H- (Dynamics of biomolecules)

缑璐, 金桃丽, 陈淑玉, 李娜, 郝东晓, 张胜利, 张磊. Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein[J]. 中国物理B, 2018, 27(2): 28708-028708.

Lu Gou(缑璐), Taoli Jin(金桃丽), Shuyu Chen(陈淑玉), Na Li(李娜), Dongxiao Hao(郝东晓), Shengli Zhang(张胜利), Lei Zhang(张磊). Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein[J]. Chin. Phys. B, 2018, 27(2): 28708-028708.

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Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein

Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein

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