Diffusional inhomogeneity in cell cultures

doi:10.1088/1674-1056/27/2/028705

中国物理B ›› 2018, Vol. 27 ›› Issue (2): 28705-028705.doi: 10.1088/1674-1056/27/2/028705

所属专题： SPECIAL TOPIC — Soft matter and biological physics

• SPECIAL TOPIC—Soft matter and biological physics • 上一篇下一篇

Diffusional inhomogeneity in cell cultures

Jia-Zheng Zhang(张佳政), Na Li(李娜), Wei Chen(陈唯)

State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China

收稿日期:2017-08-31 修回日期:2017-11-10 出版日期:2018-02-05 发布日期:2018-02-05
通讯作者: Wei Chen E-mail:phchenwei@fudan.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 11474054).

Diffusional inhomogeneity in cell cultures

Jia-Zheng Zhang(张佳政), Na Li(李娜), Wei Chen(陈唯)

State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai 200433, China

Received:2017-08-31 Revised:2017-11-10 Online:2018-02-05 Published:2018-02-05
Contact: Wei Chen E-mail:phchenwei@fudan.edu.cn
About author:87.17.Jj; 05.40.Fb; 87.18.Gh
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 11474054).

摘要/Abstract

摘要： Cell migrations in the cell cultures are found to follow non-Gaussian statistics. We recorded long-term cell migration patterns with more than six hundred cells located in 28 mm². Our experimental data support the claim that an individual cell migration follows Gaussian statistics. Because the cell culture is inhomogeneous, the statistics of the cell culture exhibit a non-Gaussian distribution. We find that the normalized histogram of the diffusion velocity follows an exponential tail. A simple model is proposed based on the diffusional inhomogeneity to explain the exponential distribution of locomotion activity in this work. Using numerical calculation, we prove that our model is in great agreement with the experimental data.

关键词: random walks, cell locomotion, collective behavior

Abstract: Cell migrations in the cell cultures are found to follow non-Gaussian statistics. We recorded long-term cell migration patterns with more than six hundred cells located in 28 mm². Our experimental data support the claim that an individual cell migration follows Gaussian statistics. Because the cell culture is inhomogeneous, the statistics of the cell culture exhibit a non-Gaussian distribution. We find that the normalized histogram of the diffusion velocity follows an exponential tail. A simple model is proposed based on the diffusional inhomogeneity to explain the exponential distribution of locomotion activity in this work. Using numerical calculation, we prove that our model is in great agreement with the experimental data.

Key words: random walks, cell locomotion, collective behavior

中图分类号: (Cell locomotion, chemotaxis)

87.17.Jj

05.40.Fb (Random walks and Levy flights) 87.18.Gh (Cell-cell communication; collective behavior of motile cells)

张佳政, 李娜, 陈唯. Diffusional inhomogeneity in cell cultures[J]. 中国物理B, 2018, 27(2): 28705-028705.

Jia-Zheng Zhang(张佳政), Na Li(李娜), Wei Chen(陈唯). Diffusional inhomogeneity in cell cultures[J]. Chin. Phys. B, 2018, 27(2): 28705-028705.

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Diffusional inhomogeneity in cell cultures

Diffusional inhomogeneity in cell cultures

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