中国物理B ›› 2017, Vol. 26 ›› Issue (5): 54302-054302.doi: 10.1088/1674-1056/26/5/054302

• ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS • 上一篇    下一篇

Noninvasive treatment efficacy monitoring and dose control for high-intensity focused ultrasound therapy using relative electrical impedance variation

Huidan Su(宿慧丹), Gepu Guo(郭各朴), Qingyu Ma(马青玉), Juan Tu(屠娟), Dong Zhang(章东)   

  1. 1 Key Laboratory of Optoelectronics of Jiangsu Province, School of Physics and Technology, Nanjing Normal University, Nanjing 210023, China;
    2 Laboratory of Modern Acoustics of Ministry of Education, Institute of Acoustics, Nanjing University, Nanjing 210093, China
  • 收稿日期:2016-10-31 修回日期:2017-01-13 出版日期:2017-05-05 发布日期:2017-05-05
  • 通讯作者: Dong Zhang E-mail:maqingyu@njnu.edu.cn
  • 基金资助:

    Project supported by the National Natural Science Foundation of China (Grant Nos. 11604156 and 11474166), the Science and Technology Cooperation Projects of China and Romania (Grant No. 42-23), the Natural Science Foundation of Jiangsu Province, China (Grant No. BK20161013), the Postdoctoral Science Foundation of China (Grant No. 2016M591874), and the Priority Academic Program Development of Jiangsu Higher Education Institutions, China.

Noninvasive treatment efficacy monitoring and dose control for high-intensity focused ultrasound therapy using relative electrical impedance variation

Huidan Su(宿慧丹)1, Gepu Guo(郭各朴)1, Qingyu Ma(马青玉)1, Juan Tu(屠娟)2, Dong Zhang(章东)2   

  1. 1 Key Laboratory of Optoelectronics of Jiangsu Province, School of Physics and Technology, Nanjing Normal University, Nanjing 210023, China;
    2 Laboratory of Modern Acoustics of Ministry of Education, Institute of Acoustics, Nanjing University, Nanjing 210093, China
  • Received:2016-10-31 Revised:2017-01-13 Online:2017-05-05 Published:2017-05-05
  • Contact: Dong Zhang E-mail:maqingyu@njnu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Grant Nos. 11604156 and 11474166), the Science and Technology Cooperation Projects of China and Romania (Grant No. 42-23), the Natural Science Foundation of Jiangsu Province, China (Grant No. BK20161013), the Postdoctoral Science Foundation of China (Grant No. 2016M591874), and the Priority Academic Program Development of Jiangsu Higher Education Institutions, China.

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摘要：

As an effective therapeutic modality, high-intensity focused ultrasound (HIFU) can destroy tumour tissues by thermocoagulation with less metastasis, but it is still limited by inaccurate non-invasive temperature monitoring and efficacy evaluation. A model of electrical impedance measurement during HIFU therapy was established using the temperature-impedance relationship. Based on the simulations of acoustic pressure, temperature, and electrical conductivity, the impedance of the phantom was calculated and experimentally demonstrated for different values of acoustic power values and treatment time. We proved that the relative impedance variation (RIV) increases linearly with the increasing treatment time at a fixed acoustic power, and the relative impedance variation rate shows a linear relationship with the acoustic power. The RIV and treatment time required for HIFU treatment efficacy are inversely proportional to the acoustic power and the square of acoustic power, respectively. The favourable results suggest that RIV can be used as an efficient indicator for noninvasive temperature monitoring and efficacy evaluation and may provide new strategy for accurate dose control of HIFU therapy.

关键词: high-intensity focused ultrasound (HIFU) therapy, relative electrical impedance variation, temperature-impedance relation, efficacy evaluation

Abstract:

As an effective therapeutic modality, high-intensity focused ultrasound (HIFU) can destroy tumour tissues by thermocoagulation with less metastasis, but it is still limited by inaccurate non-invasive temperature monitoring and efficacy evaluation. A model of electrical impedance measurement during HIFU therapy was established using the temperature-impedance relationship. Based on the simulations of acoustic pressure, temperature, and electrical conductivity, the impedance of the phantom was calculated and experimentally demonstrated for different values of acoustic power values and treatment time. We proved that the relative impedance variation (RIV) increases linearly with the increasing treatment time at a fixed acoustic power, and the relative impedance variation rate shows a linear relationship with the acoustic power. The RIV and treatment time required for HIFU treatment efficacy are inversely proportional to the acoustic power and the square of acoustic power, respectively. The favourable results suggest that RIV can be used as an efficient indicator for noninvasive temperature monitoring and efficacy evaluation and may provide new strategy for accurate dose control of HIFU therapy.

Key words: high-intensity focused ultrasound (HIFU) therapy, relative electrical impedance variation, temperature-impedance relation, efficacy evaluation

中图分类号:  (Ultrasonics, quantum acoustics, and physical effects of sound)

  • 43.35.+d
87.50.Y- (Biological effects of acoustic and ultrasonic energy) 87.50.yk (Dosimetry/exposure assessment) 87.55.N- (Radiation monitoring, control, and safety)