中国物理B ›› 2009, Vol. 18 ›› Issue (3): 1294-1300.doi: 10.1088/1674-1056/18/3/076
• 8000 CROSSDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇
王军威, 陈爱敏, 张家军, 苑占江, 周天寿
Wang Jun-Wei(王军威), Chen Ai-Min(陈爱敏), Zhang Jia-Jun(张家军), Yuan Zhan-Jiang(苑占江), and Zhou Tian-Shou(周天寿)†
摘要: In circadian rhythm generation, intercellular signaling factors are shown to play a crucial role in both sustaining intrinsic cellular rhythmicity and acquiring collective behaviours across a population of circadian neurons. However, the physical mechanism behind their role remains to be fully understood. In this paper, we propose an indirectly coupled multicellular model for the synchronization of Drosophila circadian oscillators combining both intracellular and intercellular dynamics. By simulating different experimental conditions, we find that such an indirect coupling way can synchronize both heterogeneous self-sustained circadian neurons and heterogeneous mutational damped circadian neurons. Moreover, they can also be entrained to ambient light--dark (LD) cycles depending on intercellular signaling.
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