Structural biology revolution led by technical breakthroughs in cryo-electron microscopy<xref rid="cpb_27_5_058703_fn1" ref-type="fn">*</xref><fn id="cpb_27_5_058703_fn1"><label>*</label><p>Project supported by the National Key Research and Development Program of China (Grant No. 2017YFA0504700) and the National Natural Science Foundation of China (Grant Nos. 31570732 and 31770785).</p></fn>

Structural biology revolution led by technical breakthroughs in cryo-electron microscopy**

Project supported by the National Key Research and Development Program of China (Grant No. 2017YFA0504700) and the National Natural Science Foundation of China (Grant Nos. 31570732 and 31770785).

Yin Chang-Cheng^†

(color online) Thermo-Fisher Titan Krios electron microscope (left); electronic-optical system of Titan Krios (right). The Titan Krios electron microscope is a field emission gun-type microscope, and has three-level condenser, while other electron microscopes have only two-level, and it is equipped with direct detection detector.