Uncovering the underlying physical mechanisms of biological systems via quantification of landscape and flux
Xu Li1, †, 
, Chu Xiakun1, Yan Zhiqiang1, Zheng Xiliang1, Zhang Kun1, Zhang Feng1, Yan Han1, Wu Wei1, Wang Jin1, 2, ‡,
, Chu Xiakun1, Yan Zhiqiang1, Zheng Xiliang1, Zhang Kun1, Zhang Feng1, Yan Han1, Wu Wei1, Wang Jin1, 2, ‡, Functional free energy landscape of DPO4 binding to its target DNA. Structural illustrations of DPO4 in (a) apo-state, (b) intermediate state, and (c) DNA-bound state. (d) Free energy landscape of DPO4 binding to DNA, with pie-charts representing the population distributions of DPO4 in the three states at each binding stage. (e)–(g) Free energy landscapes of DPO4 in US, EC, IS, and BS binding stages.[
