Uncovering the underlying physical mechanisms of biological systems via quantification of landscape and flux
Xu Li1, †, 
, Chu Xiakun1, Yan Zhiqiang1, Zheng Xiliang1, Zhang Kun1, Zhang Feng1, Yan Han1, Wu Wei1, Wang Jin1, 2, ‡,
, Chu Xiakun1, Yan Zhiqiang1, Zheng Xiliang1, Zhang Kun1, Zhang Feng1, Yan Han1, Wu Wei1, Wang Jin1, 2, ‡, Functional free energy landscape and kinetic analyses of ADK with substrates binding. (a) Comparison of the simulation results with the experimental measurements on the LID-CORE distance distributions, which is used to distinguish the open and closed states of ADK. (b) Free energy landscapes of ADK induced by substrates binding. (c) Illustrations of the four-state kinetic model. (d), (e) Kinetic analyses of rates and fluxes during the process of ADK realizing its function with substrates binding.[
