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Chin. Phys. B, 2018, Vol. 27(7): 078701    DOI: 10.1088/1674-1056/27/7/078701
INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY Prev   Next  

Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

Shi-Hui Chang(常诗卉)1, Rui Cao(曹睿)2, Ya-Bin Zhang(张亚斌)1,3, Pei-Guo Wang(王佩国)4, Shi-Jing Wu(吴世敬)1, Yu-Han Qian(钱宇晗)1, Xi-Qi Jian(菅喜岐)1
1 School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 300070, China;
2 College of Mechanical Engineering, Tianjin University of Science & Technology, Tianjin 300222, China;
3 Union Stem Cell & Gene Engineering Co., Ltd., Tianjin 300384, China;
4 Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
Abstract  Recently, the phase compensation technique has allowed the ultrasound to propagate through the skull and focus into the brain. However, the temperature evolution during treatment is hard to control to achieve effective treatment and avoid over-high temperature. Proposed in this paper is a method to modulate the temperature distribution in the focal region. It superimposes two signals which focus on two preset different targets with a certain distance. Then the temperature distribution is modulated by changing triggering time delay and amplitudes of the two signals. The simulation model is established based on an 82-element transducer and computed tomography (CT) data of a volunteer's head. A finite-difference time-domain (FDTD) method is used to calculate the temperature distributions. The results show that when the distances between the two targets respectively are 7.5-12.5 mm on the acoustic axis and 2.0-3.0 mm in the direction perpendicular to the acoustic axis, a focal region with a uniform temperature distribution (64-65 ℃) can be created. Moreover, the volume of the focal region formed by one irradiation can be adjusted (26.8-266.7 mm3) along with the uniform temperature distribution. This method may ensure the safety and efficacy of HIFU brain tumor therapy.
Keywords:  high-intensity focused ultrasound (HIFU)      transcranial therapy      double excitation signal superimposition      temperature modulation of focal region  
Received:  02 February 2018      Revised:  01 May 2018      Accepted manuscript online: 
PACS:  87.50.Y- (Biological effects of acoustic and ultrasonic energy)  
  87.55.Gh (Simulation)  
  87.55.dh (Tissue response)  
  87.55.de (Optimization)  
Fund: Project supported by the National Natural Science Foundation of China (Grant No. 81272495) and the Natural Science Foundation of Tianjin, China (Grant No. 16JC2DJC32200).
Corresponding Authors:  Xi-Qi Jian     E-mail:  jianxiqi@tmu.edu.cn

Cite this article: 

Shi-Hui Chang(常诗卉), Rui Cao(曹睿), Ya-Bin Zhang(张亚斌), Pei-Guo Wang(王佩国), Shi-Jing Wu(吴世敬), Yu-Han Qian(钱宇晗), Xi-Qi Jian(菅喜岐) Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound 2018 Chin. Phys. B 27 078701

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