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Chinese Physics, 2005, Vol. 14(4): 744-752    DOI: 10.1088/1009-1963/14/4/018
ATOMIC AND MOLECULAR PHYSICS Prev   Next  

Model for processive movement of myosin V and myosin VI

Xie Ping (谢平), Dou Shuo-Xing (窦硕星), Wang Peng-Ye (王鹏业)
Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China
Abstract  Myosin V and myosin VI are two classes of two-headed molecular motors of the myosin superfamily that move processively along helical actin filaments in opposite directions. Here we present a hand-over-hand model for their processive movements. In the model, the moving direction of a dimeric molecular motor is automatically determined by the relative orientation between its two heads at free state and its head's binding orientation on track filament. This determines that myosin V moves toward the barbed end and myosin VI moves toward the pointed end of actin. During the moving period in one step, one head remains bound to actin for myosin V whereas two heads are detached for myosin VI: the moving manner is determined by the length of neck domain. This naturally explains the similar dynamic behaviours but opposite moving directions of myosin VI and mutant myosin V (the neck of which is truncated to only one-sixth of the native length). Because of different moving manners, myosin VI and mutant myosin V exhibit significantly broader step-size distribution than native myosin V. However,all the three motors give the same mean step size of $\sim $36nm (the pseudo-repeat of actin helix). All these theoretical results are in agreement with previous experimental ones.
Keywords:  Myosin V      myosin VI      molecular motor      processivity      mechanism  
Received:  28 May 2004      Revised:  12 November 2004      Accepted manuscript online: 
PACS:  87.15.B- (Structure of biomolecules)  
  87.15.H- (Dynamics of biomolecules)  
  87.15.K- (Molecular interactions; membrane-protein interactions)  
  36.20.-r (Macromolecules and polymer molecules)  
Fund: Project supported by the National Natural Science Foundation of China (Grant Nos 60025516 and 10334100)

Cite this article: 

Xie Ping (谢平), Dou Shuo-Xing (窦硕星), Wang Peng-Ye (王鹏业) Model for processive movement of myosin V and myosin VI 2005 Chinese Physics 14 744

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