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Chin. Phys. B, 2020, Vol. 29(3): 038701    DOI: 10.1088/1674-1056/ab6961
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Astrocyte and ions metabolism during epileptogenesis: A review for modeling studies

Meng-Meng Du(独盟盟)1,2, Jia-Jia Li(李佳佳)1,2, Zhi-Xuan Yuan(袁治轩)1,2, Yong-Chen Fan(范永晨)1,2, Ying Wu(吴莹)1,2,3
1 State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an Jiaotong University, Xi'an 710049, China;
2 School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an 710049, China;
3 National Demonstration Center for Experimental Mechanics Education, Xi'an Jiaotong University, Xi'an 710049, China
Abstract  As a large group of cells in a central nervous system, astrocytes have a great influence on ion and energy metabolism in a nervous system. Disorders of neuronal ion and energy metabolism caused by impaired astrocytes play a key role in the pathogenesis of epilepsy. This paper reviews the existing computational models of epileptogenesis resulting from impaired astrocytes and presents several open perspectives with regard to ion and energy metabolism-induced epileptogenesis in a neuron-astrocyte-capillary coupled model.
Keywords:  epileptogenesis      astrocyte      potassium      glutamate  
Received:  22 October 2019      Revised:  23 December 2019      Accepted manuscript online: 
PACS:  87.19.lk (Glia)  
  87.19.ll (Models of single neurons and networks)  
  87.19.L- (Neuroscience)  
  87.19.lj (Neuronal network dynamics)  
Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11772242).
Corresponding Authors:  Ying Wu     E-mail:  wying36@xjtu.edu.cn

Cite this article: 

Meng-Meng Du(独盟盟), Jia-Jia Li(李佳佳), Zhi-Xuan Yuan(袁治轩), Yong-Chen Fan(范永晨), Ying Wu(吴莹) Astrocyte and ions metabolism during epileptogenesis: A review for modeling studies 2020 Chin. Phys. B 29 038701

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