Please wait a minute...
Chin. Phys. B, 2019, Vol. 28(10): 108704    DOI: 10.1088/1674-1056/ab4275
RAPID COMMUNICATION Prev   Next  

Influence of matrigel on the shape and dynamics of cancer cells

Teng Ye(叶腾)1, Feng Qiu(邱峰)1,2
First Clinical Medical College, Nanchang University, Nanchang, China, Department of Oncology, First Affiliated Hospital of Nanchang University, Nanchang, China
Abstract  

The interaction between extracellular matrices and cancer cells plays an important role in regulating cancer cell behaviors. In this article, we use matrigel to mimic extracellular matrices and investigate experimentally how matrigel influences the shape and dynamics of breast cancer cells (MDA-MB-231-GFP cells). We find that matrigel facilitates cancer cells' migration and shape deformation. The influences of the matrigel concentration are also reported.

Keywords:  cancer cell      matrigel      migration      shape deformation  
Received:  28 August 2019      Revised:  06 September 2019      Accepted manuscript online: 
PACS:  87.17.-d (Cell processes)  
  87.17.Jj (Cell locomotion, chemotaxis)  
  87.18.Ed (Cell aggregation)  
  05.40.Jc (Brownian motion)  
Corresponding Authors:  Feng Qiu     E-mail:  lukeqiubmu@163.com

Cite this article: 

Teng Ye(叶腾), Feng Qiu(邱峰) Influence of matrigel on the shape and dynamics of cancer cells 2019 Chin. Phys. B 28 108704

[1] Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred E N, Moore D H, Meli S and Gasparini G 1992 J. Natl. Cancer Inst. 84 1875
[2] Spaeth E L, Dembinski J L, Sasser A K, Watson K, Klopp A, Hall B, Andreeff M and Marini F 2009 PLoS One 4 e4992
[3] Whiteside T L 2008 Oncogene 27 5904
[4] Rejniak K A 2016 Systems Biology of Tumor Microenvironment: Quantitative Modeling and Simulations (Berlin: Springer Int Publishing AG) p. 73
[5] Hockel M and Vaupel P 2001 J. Natl. Cancer Inst. 93 266
[6] Xu R, Boudreau A and Bissell M 2009 Cancer Metastasis Rev. 28 167
[7] Coussens L M and Werb Z 1996 Chem. Biol. 3 895
[8] Hanahan D and Weinberg R A 2000 Cell 100 57
[9] Garbett E A, Reed M W R and Brown N J 1999 Br. J. Cancer 81 287
[10] Provenzano P P, Inman D R, Eliceiri K W, Knittel J G, Yan L, Rueden C T, White J G and Keely P J 2008 BMC Med. 6 11
[11] Levental K R, Yu H, Kass L, Lakins J N, Egeblad M, Erler J T, Fong S F T, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser D L and Weaver V M 2009 Cell 139 891
[12] Rowe R G and Weiss S J 2008 Trends Cell Biol. 18 560
[13] Kalluri R 2003 Nat. Rev. Cancer 3 422
[14] Kleinman H K and Martin G R 2005 Semin. Cancer Biol. 15 378
[15] Hughes C S, Postovit L M and Lajoie G A 2010 Proteomics 10 1886
[16] Price K J, Tsykin A, Giles K M, Sladic R T, Epis M R, Ganss R, Goodall G J and Leedman P J 2012 Biochem. Biophys. Res. Commun. 427 343
[17] Badea M A, Balas M, Hermenean A, Ciceu A, Herman H, Ionita D and Dinischiotu A 2019 SLAS Discovery : Advancing Life Sciences R & D 24 563
[18] Piccinini F, Kiss A and Horvath P 2016 Bioinformatics 32 955
[19] Gorelik R and Gautreau A 2014 Nat. Protoc. 9 1931
[20] Park J A, Kim J H, Bi D, et al. 2015 Nat. Mater. 14 1040
[1] Ion migration in metal halide perovskite QLEDs and its inhibition
Yuhui Dong(董宇辉), Danni Yan(严丹妮), Shuai Yang(杨帅), Naiwei Wei(魏乃炜),Yousheng Zou(邹友生), and Haibo Zeng(曾海波). Chin. Phys. B, 2023, 32(1): 018507.
[2] Inertial focusing and rotating characteristics of elliptical and rectangular particle pairs in channel flow
Pei-Feng Lin(林培锋), Xiao Hu(胡箫), and Jian-Zhong Lin(林建忠). Chin. Phys. B, 2022, 31(8): 080501.
[3] Coherence migration in high-dimensional bipartite systems
Zhi-Yong Ding(丁智勇), Pan-Feng Zhou(周攀峰), Xiao-Gang Fan(范小刚),Cheng-Cheng Liu(刘程程), Juan He(何娟), and Liu Ye(叶柳). Chin. Phys. B, 2022, 31(6): 060308.
[4] Migration and shape of cells on different interfaces
Xiaochen Wang(王晓晨), Qihui Fan (樊琪慧), and Fangfu Ye(叶方富). Chin. Phys. B, 2021, 30(9): 090502.
[5] Nonlinear dynamics of cell migration in anisotropic microenvironment
Yanping Liu(刘艳平), Da He(何达), Yang Jiao(焦阳), Guoqiang Li(李国强), Yu Zheng(郑钰), Qihui Fan(樊琪慧), Gao Wang(王高), Jingru Yao(姚静如), Guo Chen(陈果), Silong Lou(娄四龙), and Liyu Liu(刘雳宇). Chin. Phys. B, 2021, 30(9): 090505.
[6] Effect of strain on electrochemical performance of Janus MoSSe monolayer anode material for Li-ion batteries: First-principles study
Guoqing Wang(王国庆), Wenjing Qin(秦文静), and Jing Shi(石晶). Chin. Phys. B, 2021, 30(4): 046301.
[7] Taking snapshots of a moving electron wave packet in molecules using photoelectron holography in strong-field tunneling ionization
Mingrui He(何明睿), Yang Fan(樊洋), Yueming Zhou(周月明), and Peixiang Lu(陆培祥). Chin. Phys. B, 2021, 30(12): 123202.
[8] Prediction of epidemics dynamics on networks with partial differential equations: A case study for COVID-19 in China
Ru-Qi Li(李汝琦), Yu-Rong Song(宋玉蓉), and Guo-Ping Jiang(蒋国平). Chin. Phys. B, 2021, 30(12): 120202.
[9] Suppression of ion migration in perovskite materials by pulse-voltage method
Xue-Yan Wang(王雪岩), Hu Wang(王虎), Luo-Ran Chen(陈烙然), Yu-Chuan Shao(邵宇川), and Jian-Da Shao(邵建达). Chin. Phys. B, 2021, 30(11): 118104.
[10] A 3D biophysical model for cancer spheroid cell-enhanced invasion in collagen-oriented fiber microenvironment
Miaomiao Hai(海苗苗), Yanping Liu(刘艳平), Ling Xiong(熊玲), Guoqiang Li(李国强), Gao Wang(王高), Hongfei Zhang(张鸿飞), Jianwei Shuai(帅建伟), Guo Chen(陈果), Liyu Liu(刘雳宇). Chin. Phys. B, 2020, 29(9): 098702.
[11] Influence of matrix-metalloproteinase inhibitor on the interaction between cancer cells and matrigel
Teng Ye(叶腾), Fangfu Ye(叶方富), Feng Qiu(邱峰). Chin. Phys. B, 2020, 29(6): 068701.
[12] Shock-induced migration of asymmetry tilt grain boundary in iron bicrystal: A case study of Σ3 [110]
Xueyang Zhang(张学阳), Kun Wang(王昆), Jun Chen(陈军), Wangyu Hu(胡望宇), Wenjun Zhu(祝文军), Shifang Xiao(肖时芳), Huiqiu Deng(邓辉球), Mengqiu Cai(蔡孟秋). Chin. Phys. B, 2019, 28(12): 126201.
[13] Effect of elasticity mismatch on cell deformation and migration: A phase-field study
Yuanfeng Yin(尹元枫), Hui Xing(邢辉), Duyang Zang(臧渡洋), Kexin Jin(金克新). Chin. Phys. B, 2018, 27(11): 116201.
[14] High-gradient magnetic field-controlled migration of solutes and particles and their effects on solidification microstructure: A review
Tie Liu(刘铁), Qiang Wang(王强), Yi Yuan(苑轶), Kai Wang(王凯), Guojian Li(李国建). Chin. Phys. B, 2018, 27(11): 118103.
[15] Influence of adatom migration on wrinkling morphologies of AlGaN/GaN micro-pyramids grown by selective MOVPE
Jie Chen(陈杰), Pu-Man Huang(黄溥曼), Xiao-Biao Han(韩小标), Zheng-Zhou Pan(潘郑州), Chang-Ming Zhong(钟昌明), Jie-Zhi Liang(梁捷智), Zhi-Sheng Wu(吴志盛), Yang Liu(刘扬), Bai-Jun Zhang(张佰君). Chin. Phys. B, 2017, 26(6): 068101.
No Suggested Reading articles found!