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Special Issue:
TOPICAL REVIEW — 8th IUPAP International Conference on Biological Physics
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| TOPICAL REVIEW—8th IUPAP International Conference on Biological Physics |
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In vitro three-dimensional cancer metastasis modeling: Past, present, and future |
| Wei-jing Han(韩伟静)1, Wei Yuan(袁伟)2, Jiang-rui Zhu(朱江瑞)1, Qihui Fan(樊琪慧)1, Junle Qu(屈军乐)2, Li-yu Liu(刘雳宇)1, on behalf of the U.S.--China Physical Sciences-Oncology Alliance |
1. Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;
2. Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, China |
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Abstract Metastasis is the leading cause of most cancer deaths, as opposed to dysregulated cell growth of the primary tumor. Molecular mechanisms of metastasis have been studied for decades and the findings have evolved our understanding of the progression of malignancy. However, most of the molecular mechanisms fail to address the causes of cancer and its evolutionary origin, demonstrating an inability to find a solution for complete cure of cancer. After being a neglected area of tumor biology for quite some time, recently several studies have focused on the impact of the tumor microenvironment on cancer growth. The importance of the tumor microenvironment is gradually gaining attention, particularly from the perspective of biophysics. In vitro three-dimensional (3-D) metastatic models are an indispensable platform for investigating the tumor microenvironment, as they mimic the in vivo tumor tissue. In 3-D metastatic in vitro models, static factors such as the mechanical properties, biochemical factors, as well as dynamic factors such as cell-cell, cell-ECM interactions, and fluid shear stress can be studied quantitatively. With increasing focus on basic cancer research and drug development, the in vitro 3-D models offer unique advantages in fundamental and clinical biomedical studies.
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Received: 02 July 2015
Revised: 05 August 2015
Accepted manuscript online:
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PACS:
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87.19.xj
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(Cancer)
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87.17.Uv
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(Biotechnology of cell processes)
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87.85.dh
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(Cells on a chip)
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87.17.Jj
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(Cell locomotion, chemotaxis)
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| Fund: Project supported by the National Basic Research Program of China (Grant No. 2013CB837200), the National Natural Science Foundation of China (Grant No. 11474345), and the Beijing Natural Science Foundation, China (Grant No. 7154221). |
Corresponding Authors:
Wei-jing Han, Wei Yuan, Li-yu Liu
E-mail: liu@iphy.ac.cn
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Cite this article:
Wei-jing Han(韩伟静), Wei Yuan(袁伟), Jiang-rui Zhu(朱江瑞), Qihui Fan(樊琪慧), Junle Qu(屈军乐), Li-yu Liu(刘雳宇), on behalf of the U.S.--China Physical Sciences-Oncology Alliance In vitro three-dimensional cancer metastasis modeling: Past, present, and future 2016 Chin. Phys. B 25 018709
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