A thermo-fluid analysis in magnetic hyperthermia

doi:10.1088/1674-1056/23/4/044401

Abstract In the last years, hyperthermia induced by the heating of magnetic nanoparticles (MNPs) in an alternating magnetic field received considerable attention in cancer therapy. The thermal effects could be automatically controlled by using MNPs with selective magnetic absorption properties. In this paper, we analyze the temperature field determined by the heating of MNPs, injected in a malignant tissue, subjected to an alternating magnetic field. The main parameters which have a strong influence on temperature field are analyzed. The temperature evolution within healthy and tumor tissues are analyzed by finite element method (FEM) simulations in a thermo-fluid model. The cooling effect produced by blood flow in blood vessels from the tumor is considered. A thermal analysis is conducted under different distributions of MNP injection sites. The interdependence between the optimum dose of the nanoparticles and various types of tumors is investigated in order to understand their thermal effect on hyperthermia therapy. The control of the temperature field in the tumor and healthy tissues is an important step in the healing treatment.

Keywords: hyperthermia magnetic nanoparticles Bioheat equations

Received: 27 July 2013
Revised: 13 September 2013
Accepted manuscript online:

PACS:	44.10.+i	(Heat conduction)
	44.05.+e	(Analytical and numerical techniques)
	87.85.J-	(Biomaterials)

Fund: Project supported by the Parteneriate HYPERTHERMIA (Grant No. 148/2012).

Corresponding Authors: Iordana Astefanoaei
E-mail: iordana@uaic.ro

About author: 44.10.+i; 44.05.+e; 87.85.J-

Cite this article:

Iordana Astefanoaei, Ioan Dumitru, Alexandru Stancu, Horia Chiriac A thermo-fluid analysis in magnetic hyperthermia 2014 Chin. Phys. B 23 044401

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