Biexponential distribution of open times of a toy channel model

doi:10.1088/1674-1056/26/12/128703

Abstract

The biexponential distributions of open times are observed in various types of ion channels. In this paper, by discussing a simple channel model, we show that there are two different schemes to understand the biexponential distribution of open times. One scheme is mathematically strict based on generator matrix theory, while the other one has a clear physical explanation according to an approximation process with numerical simulation of Markovian channel dynamics. Our comparison results suggest that even for biologically complex channels, in addition to carrying out a stochastic simulation, the strict theoretical analysis should be considered to understand the multiple exponential distributions of open times.

Keywords: ion channel biexponential distribution generator matrix theory Markovian simulation

Received: 31 August 2017
Revised: 09 September 2017
Accepted manuscript online:

PACS:	87.16.Vy	(Ion channels)
	87.50.cf	(Biophysical mechanisms of interaction)
	87.17.Aa	(Modeling, computer simulation of cell processes)

Fund:

Project supported by the National Natural Science Foundations of China (Grant Nos. 11504214, 31370830, and 11675134), the 111 Project, China (Grant No. B16029), and the China Postdoctoral Science Foundation (Grant No. 2016M602071).

Corresponding Authors: Hong Qi
E-mail: hongqi@sxu.edu.cn

Cite this article:

Xiang Li(李翔), Jing-Jing Zhong(钟金金), Xue-Juan Gao(高学娟), Yu-Ning Wu(吴宇宁), Jian-Wei Shuai(帅建伟), Hong Qi(祁宏) Biexponential distribution of open times of a toy channel model 2017 Chin. Phys. B 26 128703

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