Detection of HIV-1 antigen based on magnetic tunnel junction sensors

doi:10.1088/1674-1056/ab928d

Abstract

We report a p24 (HIV disease biomarker) detection assay using an MgO-based magnetic tunnel junction (MTJ) sensor and 20-nm magnetic nanoparticles. The MTJ array sensor with sensing area of 890×890 μ² possessing a sensitivity of 1.39%/Oe was used to detect p24 antigens. It is demonstrated that the p24 antigens could be detected at a concentration of 0.01 μg/ml. The development of bio-detection systems based on magnetic tunnel junction sensors with high-sensitivity will greatly benefit the early diagnosis of HIV.

Keywords: MgO-based magnetic tunnel junction sensor HIV bio-detection system antigen p24 early disease diagnosis

Received: 17 March 2020
Revised: 05 May 2020
Accepted manuscript online:

PACS:	87.85.Rs	(Nanotechnologies-applications)
	87.85.Qr	(Nanotechnologies-design)
	85.75.Ss	(Magnetic field sensors using spin polarized transport)
	87.85.fk	(Biosensors)

Fund:

Project supported by President's Fund of CUHKSZ, Longgang Key Laboratory of Applied Spintronics, at The Chinese University of Hong Kong, the National Natural Science Foundation of China (Grant Nos. 11974298 and 61961136006), the Shenzhen Fundamental Research Fund, China (Grant No. JCYJ20170410171958839), and Shenzhen Peacock Group Plan, China (Grant No. KQTD20180413181702403).

Corresponding Authors: Yan Zhou
E-mail: zhouyan@cuhk.edu.cn

Cite this article:

Li Li(李丽), Kai-Yu Mak(麦启宇), Yan Zhou(周艳) Detection of HIV-1 antigen based on magnetic tunnel junction sensors 2020 Chin. Phys. B 29 088701

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