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Influence of matrix-metalloproteinase inhibitor on the interaction between cancer cells and matrigel |
| Teng Ye(叶腾)1, Fangfu Ye(叶方富)2,3, Feng Qiu(邱峰)1,4 |
1 First Clinical Medical College, Nanchang University, Nanchang 330006, China;
2 Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;
3 Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China;
4 Department of Oncology, First Affiliated Hospital of Nanchang University, Nanchang 330006, China |
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Abstract Various behaviors of cancer cells are strongly influenced by their interaction with extracellular matrices (ECM). We investigate how this interaction may be influenced if the cancer cells' ability of secreting matrix metalloproteinases (MMPs) to degrade ECM is inhibited by adding the MMP inhibitor. We use MDA-MB-231-GFP cells as model cells and use matrigel to mimic ECM. It is found that the added MMP inhibitor significantly reduces the migration speed of cancer cells covered by matrigel but has little influence on the migration persistence and shape factor of the cells and that with the MMP inhibitor added the presence of matrigel on the top has no influence on the migration speed of the cells but increases the cells' shape factor and migration persistence.
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Received: 14 February 2020
Revised: 31 March 2020
Accepted manuscript online:
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PACS:
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87.17.-d
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(Cell processes)
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87.17.Jj
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(Cell locomotion, chemotaxis)
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87.18.Ed
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(Cell aggregation)
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05.40.Jc
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(Brownian motion)
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| Fund: Project supported by the National Natural Science Foundation of China (Grant No. 11774394), the Key Research Program of Frontier Sciences of Chinese Academy of Sciences (Grant No. QYZDB-SSW-SYS003), and the K.C. Wong Education Foundation. |
Corresponding Authors:
Fangfu Ye, Feng Qiu
E-mail: fye@iphy.ac.cn;lukeqiubmu@163.com
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Cite this article:
Teng Ye(叶腾), Fangfu Ye(叶方富), Feng Qiu(邱峰) Influence of matrix-metalloproteinase inhibitor on the interaction between cancer cells and matrigel 2020 Chin. Phys. B 29 068701
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