Oscillatory and anti-oscillatory motifs in genetic regulatory networks

doi:10.1088/1674-1056/21/6/060203

Abstract Recently, self-sustained oscillatory genetic regulatory networks (GRNs) have attracted significant attention in the biological field. Given a GRN, it is important to anticipate whether the network could generate oscillation with proper parameters, and what the key ingredients for the oscillation are. In this paper the ranges of some function-related parameters which are favorable to sustained oscillations are considered. In particular, some oscillatory motifs appearing with high-frequency in most of the oscillatory GRNs are observed. Moreover, there are some anti-oscillatory motifs which have a strong oscillation repressing effect. Some conclusions analyzing these motif effects and constructing oscillatory GRNs are provided.

Keywords: genetic regulatory network oscillatory motif anti-oscillatory motif feedback loop

Received: 21 December 2011
Revised: 17 February 2012
Accepted manuscript online:

PACS:	02.60.Cb	(Numerical simulation; solution of equations)
	05.65.+b	(Self-organized systems)
	87.15.A-	(Theory, modeling, and computer simulation)
	87.18.Cf	(Genetic switches and networks)

Fund: Project supported by the National Natural Science Foundation of China (Grant No. 10975015) and the National Basic Research Program of China (Grant No. 2007CB814800).

Corresponding Authors: Hu Gang
E-mail: ganghu@bnu.edu.cn

Cite this article:

Ye Wei-Ming(叶纬明), Zhang Zhao-Yang(张朝阳), LŰ Bin-Bin(吕彬彬), Di Zeng-Ru(狄增如), and Hu Gang(胡岗) Oscillatory and anti-oscillatory motifs in genetic regulatory networks 2012 Chin. Phys. B 21 060203

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