Potential dynamic analysis of tumor suppressor p53 regulated by Wip1 protein

doi:10.1088/1674-1056/ab84d1

中国物理B ›› 2020, Vol. 29 ›› Issue (6): 68704-068704.doi: 10.1088/1674-1056/ab84d1

• INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY • 上一篇

Potential dynamic analysis of tumor suppressor p53 regulated by Wip1 protein

Nan Liu(刘楠), Dan-Ni Wang(王丹妮), Hai-Ying Liu(刘海英), Hong-Li Yang(杨红丽), Lian-Gui Yang(杨联贵)

School of Mathematical Sciences, Inner Mongolia University, Hohhot 010021, China

收稿日期:2020-01-12 修回日期:2020-03-28 出版日期:2020-06-05 发布日期:2020-06-05
通讯作者: Hong-Li Yang E-mail:imuyhl@imu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 11762011).

Potential dynamic analysis of tumor suppressor p53 regulated by Wip1 protein

Nan Liu(刘楠), Dan-Ni Wang(王丹妮), Hai-Ying Liu(刘海英), Hong-Li Yang(杨红丽), Lian-Gui Yang(杨联贵)

School of Mathematical Sciences, Inner Mongolia University, Hohhot 010021, China

Received:2020-01-12 Revised:2020-03-28 Online:2020-06-05 Published:2020-06-05
Contact: Hong-Li Yang E-mail:imuyhl@imu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 11762011).

摘要/Abstract

摘要： The tumor suppressor p53 plays a key role in protecting genetic integrity. Its dynamics have important physiological significance, which may be related to the cell fate. Previous experiments have shown that the wild-type p53-induced phosphatase 1 (Wip1) protein could maintain p53 oscillation. Therefore, we add Wip1 to remodel the p53 network. Firstly, we use the binomial τ-leap algorithm to prove our model stable under internal noise. Then, we make a series of bifurcation diagrams, that is, p53 levels as a function of p53 degradation rate at different Wip1 generation rates. The results illustrate that Wip1 is essential for p53 oscillation. Finally, a two-dimensional bifurcation diagram is made and the stability of some p53 dynamics under external noise is analyzed by potential landscape. Our results may have some implications for artificially interfering with p53 dynamics to achieve tumor suppression.

关键词: Wip1, p53-dynamics, oscillation

Abstract: The tumor suppressor p53 plays a key role in protecting genetic integrity. Its dynamics have important physiological significance, which may be related to the cell fate. Previous experiments have shown that the wild-type p53-induced phosphatase 1 (Wip1) protein could maintain p53 oscillation. Therefore, we add Wip1 to remodel the p53 network. Firstly, we use the binomial τ-leap algorithm to prove our model stable under internal noise. Then, we make a series of bifurcation diagrams, that is, p53 levels as a function of p53 degradation rate at different Wip1 generation rates. The results illustrate that Wip1 is essential for p53 oscillation. Finally, a two-dimensional bifurcation diagram is made and the stability of some p53 dynamics under external noise is analyzed by potential landscape. Our results may have some implications for artificially interfering with p53 dynamics to achieve tumor suppression.

Key words: Wip1, p53-dynamics, oscillation

中图分类号: (Dynamical, regulatory, and integrative biology)

87.85.Xd

87.57.cm (Noise) 82.40.Bj (Oscillations, chaos, and bifurcations) 82.39.Rt (Reactions in complex biological systems)

刘楠, 王丹妮, 刘海英, 杨红丽, 杨联贵. Potential dynamic analysis of tumor suppressor p53 regulated by Wip1 protein[J]. 中国物理B, 2020, 29(6): 68704-068704.

Nan Liu(刘楠), Dan-Ni Wang(王丹妮), Hai-Ying Liu(刘海英), Hong-Li Yang(杨红丽), Lian-Gui Yang(杨联贵). Potential dynamic analysis of tumor suppressor p53 regulated by Wip1 protein[J]. Chin. Phys. B, 2020, 29(6): 68704-068704.

参考文献 32

[1]	Vousden K H and Prives C 2009 Cell 137 413 doi: 10.1016/j.cell.2009.04.037
[2]	Kastan M B, Onyekwere O, Sidransky D, Vogelstein B and Craig R W 1991 Cancer Res. 51 6304
[3]	Sengupta S and Harris C C 2005 Nat. Rev. Mol. Cell Biol. 6 44 doi: 10.1038/nrm1546
[4]	Elmore S 2007 J. Toxicol Pathol 35 495 doi: 10.1080/01926230701320337
[5]	Purvis J E, Karhohs K W, Mock C, Batchelor E, Loewer A and Lahav G 2012 Science 336 1440 doi: 10.1126/science.1218351
[6]	Zhang Q H, Tian X J, Liu F and Wang W 2014 FEBS Lett. 588 4369 doi: 10.1016/j.febslet.2014.09.043
[7]	Zhang X P, Liu F, Cheng Z and Wang W 2009 Proc. Natl. Acad. Sci. USA 106 12245 doi: 10.1073/pnas.0813088106
[8]	Sun T, Chen C, Wu Y, Zhang S, Cui J and Shen P 2009 BMC Bioinformatics 10 190 doi: 10.1186/1471-2105-10-190
[9]	Li J, Yang Y, Peng Y et al. 2002 Nat. Genetics 31 133 doi: 10.1038/ng888
[10]	Rauta J, Alarmo E L, Kauraniemi P, Karhu R, Kuukasjärvi T and Kallioniemi A 2006 Breast Cancer Res. Treat. 95 257 doi: 10.1007/s10549-005-9017-7
[11]	Hirrison M, Li J, Degenhardt Y, Hoey T and Powers S 2004 Trends Mol. Med. 10 359 doi: 10.1016/j.molmed.2004.06.010
[12]	Bulavin D V, Demidov O N, Saito S et al. 2002 Nat. Genet. 31 210 doi: 10.1038/ng894
[13]	Lev B R, Maya R, Segel L A, Alon U, Levine A J and Oren M 2000 Proc. Natl. Acad. Sci. USA 97 11250 doi: 10.1073/pnas.210171597
[14]	Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine A J, Elowitz M B and Alon U 2004 Nat. Genet. 36 147 doi: 10.1038/ng1293
[15]	Batchelor E, Mock C S, Bhan I, Loewer A and Lahav G 2008 Mol. Cell 30 277 doi: 10.1016/j.molcel.2008.03.016
[16]	Zhang X P, Liu F and Wang W 2011 Proc. Natl. Acad. Sci. USA 108 8990 doi: 10.1073/pnas.1100600108
[17]	Sun T Z, Yang W, Liu J and Shen P P 2011 PLoS. ONE 6 e27882
[18]	Wang D G, Zhou C H and Zhang X P 2017 Chin. Phys. B 26 128709 doi: 10.1088/1674-1056/26/12/128709
[19]	Wang J, Li X and Wang E 2008 Proc. Natl. Acad. Sci. USA 105 12271 doi: 10.1073/pnas.0800579105
[20]	Li C and Ye L 2019 J. Chem. Phys. 151 175101 doi: 10.1063/1.5125046
[21]	Bi Y H, Yang Z Q and He X Y 2016 Acta. Phys. Sin. 65 028701 (in Chinese)
[22]	Xia J F and Jia Y 2010 Chin. Phys. B 19 040506 doi: 10.1088/1674-1056/19/4/040506
[23]	Zhuo Y Z, Yan S W and Zhang L J 2007 Acta. Phys. Sin. 56 2442 (in Chinese)
[24]	Zhang T, Brazhnik P and Tyson J J 2007 Cell Cycle 6 85 doi: 10.4161/cc.6.1.3705
[25]	Zhuge C, Sun X, Chen Y and Lei J 2016 J. Theor. Biol. 388 1 doi: 10.1016/j.jtbi.2015.09.025
[26]	Levine A J 1997 Cell 88 323 doi: 10.1016/S0092-8674(00)81871-1
[27]	Falck J, Coates J and Jackson S P 2005 Nature 434 605 doi: 10.1038/nature03442
[28]	Prives C 1998 Cell 95 5
[29]	Stommel J M and Wahl G M 2004 EMBO J. 23 1547 doi: 10.1038/sj.emboj.7600145
[30]	Hamard P J and Manfredi J J 2012 Cancer Cell 21 3 doi: 10.1016/j.ccr.2011.12.018
[31]	Wang D G, Wang S B, Huang B and Liu F 2019 Sci. Rep. 9 5883 doi: 10.1038/s41598-019-41904-9
[32]	Zhang X P, Liu F and Wang W 2012 Biophys. J. 102 2251 doi: 10.1016/j.bpj.2012.04.002

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