Effects of abnormal excitation on the dynamics of spiral waves

doi:10.1088/1674-1056/25/1/010504

中国物理B ›› 2016, Vol. 25 ›› Issue (1): 10504-010504.doi: 10.1088/1674-1056/25/1/010504

Effects of abnormal excitation on the dynamics of spiral waves

Min-Yi Deng(邓敏艺), Xue-Liang Zhang(张学良), Jing-Yu Dai(戴静娱)

College of Physical Science and Technology, Guangxi Normal University, Guilin 541004, China

收稿日期:2015-06-29 修回日期:2015-08-14 出版日期:2016-01-05 发布日期:2016-01-05
通讯作者: Min-Yi Deng E-mail:dengminyi@mailbox.gxnu.edu.cn
基金资助:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11365003 and 11165004).

Effects of abnormal excitation on the dynamics of spiral waves

Min-Yi Deng(邓敏艺), Xue-Liang Zhang(张学良), Jing-Yu Dai(戴静娱)

College of Physical Science and Technology, Guangxi Normal University, Guilin 541004, China

Received:2015-06-29 Revised:2015-08-14 Online:2016-01-05 Published:2016-01-05
Contact: Min-Yi Deng E-mail:dengminyi@mailbox.gxnu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Grant Nos. 11365003 and 11165004).

摘要/Abstract

摘要： The effect of physiological and pathological abnormal excitation of a myocyte on the spiral waves is investigated based on the cellular automaton model. When the excitability of the medium is high enough, the physiological abnormal excitation causes the spiral wave to meander irregularly and slowly. When the excitability of the medium is low enough, the physiological abnormal excitation leads to a new stable spiral wave. On the other hand, the pathological abnormal excitation destroys the spiral wave and results in the spatiotemporal chaos, which agrees with the clinical conclusion that the early after depolarization is the pro-arrhythmic mechanism of some anti-arrhythmic drugs. The mechanisms underlying these phenomena are analyzed.

关键词: cellular automaton, abnormal excitation, transmembrane potential, spiral wave

Abstract: The effect of physiological and pathological abnormal excitation of a myocyte on the spiral waves is investigated based on the cellular automaton model. When the excitability of the medium is high enough, the physiological abnormal excitation causes the spiral wave to meander irregularly and slowly. When the excitability of the medium is low enough, the physiological abnormal excitation leads to a new stable spiral wave. On the other hand, the pathological abnormal excitation destroys the spiral wave and results in the spatiotemporal chaos, which agrees with the clinical conclusion that the early after depolarization is the pro-arrhythmic mechanism of some anti-arrhythmic drugs. The mechanisms underlying these phenomena are analyzed.

Key words: cellular automaton, abnormal excitation, transmembrane potential, spiral wave

中图分类号: (Nonlinear dynamics and chaos)

05.45.-a

87.18.Hf (Spatiotemporal pattern formation in cellular populations)

邓敏艺, 张学良, 戴静娱. Effects of abnormal excitation on the dynamics of spiral waves[J]. 中国物理B, 2016, 25(1): 10504-010504.

Min-Yi Deng(邓敏艺), Xue-Liang Zhang(张学良), Jing-Yu Dai(戴静娱). Effects of abnormal excitation on the dynamics of spiral waves[J]. Chin. Phys. B, 2016, 25(1): 10504-010504.

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Effects of abnormal excitation on the dynamics of spiral waves

Effects of abnormal excitation on the dynamics of spiral waves

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