Radiation-induced robust oscillation [2mm]and non-Gaussian fluctuation

doi:10.1088/1674-1056/20/12/128702

中国物理B ›› 2011, Vol. 20 ›› Issue (12): 128702-128702.doi: 10.1088/1674-1056/20/12/128702

Radiation-induced robust oscillation [2mm]and non-Gaussian fluctuation

耿轶钊¹, 晏世伟², 刘波³

(1)College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875, China; (2)College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875, China;Beijing Radiation Centre, Beijing 100875, China;Centre of Theoretical Physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000, China; (3)Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;Key Laboratory of Beam Technology and Material Modification of Ministry of Education, Beijing Norma

收稿日期:2010-09-07 修回日期:2011-08-16 出版日期:2011-12-15 发布日期:2011-12-15
基金资助:
Project supported by the National Natural Science Foundation of China (Grant No. 10975019), the Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Personnel of China (Grant No. MOP2006138), the Fundamental Research Funds for the Central Universities, and the Science Foundation of the Ministry of Science and Technology of China (Grant No. 2012CB934001).

Radiation-induced robust oscillation and non-Gaussian fluctuation

Liu Bo(刘波)^a)b)c)^†, Yan Shi-Wei (晏世伟)^c)d)e), and Geng Yi-Zhao(耿轶钊)^c)

^a Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China; ^b Key Laboratory of Beam Technology and Material Modification of Ministry of Education, Beijing Normal University, Beijing 100875, China; ^c College of Nuclear Science and Technology, Beijing Normal University, Beijing 100875, China; ^dBeijing Radiation Centre, Beijing 100875, China; ^eCentre of Theoretical Physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000, China

Received:2010-09-07 Revised:2011-08-16 Online:2011-12-15 Published:2011-12-15
Supported by:
Project supported by the National Natural Science Foundation of China (Grant No. 10975019), the Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Personnel of China (Grant No. MOP2006138), the Fundamental Research Funds for the Central Universities, and the Science Foundation of the Ministry of Science and Technology of China (Grant No. 2012CB934001).

摘要/Abstract

摘要： There have been many recent studies devoted to the consequences of stochasticity in protein circuitry. Stress conditions, including DNA damage, hypoxia, heat shock, nutrient deprivation, and oncogene activation, can result in the activation and accumulation of p53. Several experimental studies show that oscillations can be induced by DNA damage following nuclear irradiation. To explore the underlying dynamical features and the role of stochasticity, we discuss the oscillatory dynamics in the well-studied regulatory network motif. The fluctuations around the fixed point of a delayed system are Gaussian in the limit of sufficiently weak delayed feedback, and remain Gaussian along a limit cycle when viewed tangential to the trajectory. The experimental results are recapitulated in this study. We illustrate several features of the p53 activities, which are robust when the parameters change. Furthermore, the distribution in protein abundance can be characterized by its non-Gaussian nature.

关键词: nuclear radiation, DNA damage, non-Gaussian activity, robustness

Abstract: There have been many recent studies devoted to the consequences of stochasticity in protein circuitry. Stress conditions, including DNA damage, hypoxia, heat shock, nutrient deprivation, and oncogene activation, can result in the activation and accumulation of p53. Several experimental studies show that oscillations can be induced by DNA damage following nuclear irradiation. To explore the underlying dynamical features and the role of stochasticity, we discuss the oscillatory dynamics in the well-studied regulatory network motif. The fluctuations around the fixed point of a delayed system are Gaussian in the limit of sufficiently weak delayed feedback, and remain Gaussian along a limit cycle when viewed tangential to the trajectory. The experimental results are recapitulated in this study. We illustrate several features of the p53 activities, which are robust when the parameters change. Furthermore, the distribution in protein abundance can be characterized by its non-Gaussian nature.

Key words: nuclear radiation, DNA damage, non-Gaussian activity, robustness

中图分类号: (Regulatory genetic and chemical networks)

87.16.Yc

87.18.Tt (Noise in biological systems) 05.40.-a (Fluctuation phenomena, random processes, noise, and Brownian motion)

刘波, 晏世伟, 耿轶钊. Radiation-induced robust oscillation [2mm]and non-Gaussian fluctuation[J]. 中国物理B, 2011, 20(12): 128702-128702.

Liu Bo(刘波), Yan Shi-Wei (晏世伟), and Geng Yi-Zhao(耿轶钊) . Radiation-induced robust oscillation and non-Gaussian fluctuation[J]. Chin. Phys. B, 2011, 20(12): 128702-128702.

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Radiation-induced robust oscillation [2mm]and non-Gaussian fluctuation

Radiation-induced robust oscillation and non-Gaussian fluctuation

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