中国物理B ›› 2014, Vol. 23 ›› Issue (7): 78705-078705.doi: 10.1088/1674-1056/23/7/078705

所属专题: TOPICAL REVIEW — Statistical Physics and Complex Systems

• TOPICAL REVIEW—Statistical Physics and Complex Systems • 上一篇    下一篇

Proteins:From sequence to structure

郑伟谋   

  1. Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China
  • 收稿日期:2014-03-02 修回日期:2014-06-13 出版日期:2014-07-15 发布日期:2014-07-15
  • 基金资助:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 11175224 and 11121403).

Proteins:From sequence to structure

Zheng Wei-Mou (郑伟谋)   

  1. Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 100190, China
  • Received:2014-03-02 Revised:2014-06-13 Online:2014-07-15 Published:2014-07-15
  • Contact: Zheng Wei-Mou E-mail:zheng@itp.ac.cn
  • About author:87.14.E; 87.15.B; 87.15.Cc
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Grant Nos. 11175224 and 11121403).

摘要: Protein sequences as special heterogeneous sequences are rare in the amino acid sequence space. The specific sequential order of amino acids of a protein is essential to its 3D structure. On the whole, the correlation between sequence and structure of a protein is not so strong. How well would a protein sequence contain its structural information? How does a sequence determine its native structure? Keeping the globular proteins in mind, we discuss several problems from sequence to structure.

关键词: proteins, protein sequence, protein structures, protein folding

Abstract: Protein sequences as special heterogeneous sequences are rare in the amino acid sequence space. The specific sequential order of amino acids of a protein is essential to its 3D structure. On the whole, the correlation between sequence and structure of a protein is not so strong. How well would a protein sequence contain its structural information? How does a sequence determine its native structure? Keeping the globular proteins in mind, we discuss several problems from sequence to structure.

Key words: proteins, protein sequence, protein structures, protein folding

中图分类号: 

  • 87.14.E
87.15.Cc (Folding: thermodynamics, statistical mechanics, models, and pathways)